![]() In addition, because most causal variants have been observed to be consistent across ancestries 11, 12, 13, MATCH-TWAS can suffer from substantial power loss by using only the GWAS data from the matched ancestry, due simply to smaller sample size. MATCH-TWAS may be difficult or even impossible to implement in practice because eQTL data may not be broadly available for disease-relevant tissues in non-European ancestries. An alternative strategy is to use ancestry-matched eQTL data from disease-relevant tissues and perform TWAS separately for each ancestry (which we call MATCH-TWAS). The results may also be difficult to interpret because causal variants underlying GWAS hits or eQTLs may differ between ancestries. Direct integration of eQTLs with GWAS data from nonmatched ancestries (for example, integrating European-derived eQTLs with non-European GWASs) was shown to have suboptimal power 10. TWAS in its original form requires GWAS and eQTL data to be from matched ancestries. Various TWAS methods have been widely applied to different complex traits to understand the functional consequences of regulatory variations 7, 8, 9. TWAS approaches (for example, FUSION 3, TIGAR 4, PrediXcan 5 and UTMOST 6) use eQTLs to predict gene expression levels in silico, which the method then uses to identify genes associated with the phenotype of interest. In the present study, we combined GWAS datasets totaling 1.3 million individuals: 1.2 million from the GWAS and Sequencing Consortium of Alcohol and Nicotine use (GSCAN) and 150,000 diverse ancestries from the Trans-Omics Precision Medicine (TOPMed) 2 to further empower gene discovery and elucidate the genetic architecture of smoking behavior.ĭissecting the mechanisms of GWAS hits for tobacco use is crucial to understand the etiology of nicotine addiction and related disease outcomes. On top of this, the genetic architecture of tobacco use outside of European populations remains understudied. Although some of these associations point to genes and pathways of known biological importance, including the nicotinic receptor and dopaminergic signaling pathway genes 1, the underlying mechanisms for most of the identified loci are unknown. The availability of large datasets has enabled a breakthrough in the genetics of smoking addiction, with >400 loci discovered to date 1. In silico drug-repurposing analyses highlight several drugs with known efficacy, including dextromethorphan and galantamine, and new drugs such as muscle relaxants that may be repurposed for treating nicotine addiction.Ĭigarette smoking is a major heritable risk factor for human diseases. These hits and subsequent fine mapping using TESLA point to target genes with biological relevance. When applied to tobacco use phenotypes, TESLA identified 273 new genes, up to 55% more compared with alternative TWAS methods. By exploiting shared phenotypic effects between ancestries and accommodating potential effect heterogeneities, TESLA improves power over other TWAS methods. We developed a new approach, TESLA (multi-ancestry integrative study using an optimal linear combination of association statistics), to integrate an eQTL dataset with a multi-ancestry GWAS. ![]() To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancestries. ![]() Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. Nature Genetics volume 55, pages 291–300 ( 2023) Cite this article Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing
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![]() Dominguez also served on the Boards of R&G Federal and Puerto Rico International Bank. Dominguez was a major shareholder and member of the Board of Directors of Caribbean Federal Saving Bank and was actively involved in the acquisition negotiations that led to the sale of Caribbean Federal to R&G Federal Savings Bank. Dominguez received an Executive Management Certificate from University of Pennsylvania’s Wharton School of Business, a Masters Degree in Finance from Inter-American University and received a Bachelors Degree in Finance from the University of Puerto Rico. Dominguez also worked for Paine Webber of Puerto Rico. ![]() and a member of the firm’s Million Dollar Club. Dominguez was a Partner and Senior Vice President with Drexel Burnham Lambert, Inc. Dominguez was consistently selected for membership in Dean Witter’s exclusive Chairman’s Club. Dominguez was the firm’s top taxable fixed income securities producer throughout Dean Witter’s offices worldwide and, based on such efforts, Mr. Prior to forming RD Capital, Mr Dominguez was a Senior Vice President and Co-Branch Manager of Dean Witter Reynolds Inc. RD Capital is one of the largest locally-owned and headquartered securities firms in Puerto Rico. (“RD Capital”), which is a privately-owned, FINRA-member brokerage firm with a full service office located in San Juan, PR. Dominguez is Chairman, Chief Executive Officer, President, and Founder of RD Capital Group, Inc. Ramon Dominguez ( Dominguez is a Series 7 General Securities Representative, Series 8 General Securities Sales Supervisor, Series 24 General Securities Principal, Series 63 Corporate Securities Representative, and Series 79 Investment Banking Representative. They can be used for a range of applications, such as crafting a romantic atmosphere for date night or providing a beautiful scenery for your upcoming event. Moreover, galaxy star projectors are incredibly functional. The vibrant shades and patterns can help reduce stress and make an idyllic atmosphere for after a long day. It can change any room into a captivating area for relaxation, meditation, or amusement. Benefits of Owning a Galaxy ProjectorĪ galaxy light projector offers numerous advantages. Lean back and let’s explore the marvels of Galaxy Projector together. Whether you are looking for a romantic date night, an enchanting place for meditation, or a striking atmosphere for your next get-together, a galaxy projector will make the ideal backdrop. Factors to Consider before Buying a Galaxy Projector-įrom the most current technology to the most economical choices, we will go through the pros and cons of each one to ensure you make a well-thought-out decision.You can also control the brightness, angle and combination of light options.Įditor’s note: Descriptions and features are taken from manufacturer/seller claims and user reviews. This super easy-to-use projector offers three light options: star, nebula cloud and the moon. Sky LED Projector Night Light – $49.99 Image: ALED Light ![]() Café 63 Star Night Light For Kids – now $26.99 (was $39.99) Image: Cafe 63Ī projector with modes covering a starry sky and a universe pattern, as well as a happy birthday message and a cover so it can do double duty as a night light. While the focus is more on projected water patterns, this projector comes with included speakers if you want music with your light shows. Tomnew Remote Control Ocean Wave Projector – now $33.99 (was $39.99) Image: Tomnew Precision glass optics give this skylight a hyper-real element. BlissLite Sky Lights 2.0 – now $59.99 (was $89.99) Image: BlissLights Simple to use and perfect for children, this will serve as a wondrous night light. The essential features are basically just a light source and a star pattern of some sort, but there’s quite a bit of scope for a galaxy projector to do more than that. Some models will offer differing star fields, or planets and galaxies, while others may include embedded music or other added features. To be just a touch more precise, it’s a catch-all term for projectors that typically project some kind of starfield, usually designed to be pointed at the ceiling of a room. It’s a projector that projects galaxies, as the name suggests. If you want to know more about filling your home with some nifty pockets of intergalactic goodness, check out some of the best deals we’ve found below. Or plug it into a smart plug, so you can set routines that you can control with your voice? Why not pair one with a mini projector and create a home cinema on a rainy day? It’ll feel just like a movie under the stars. With the flick of a switch, you can totally change the mood of a room without needing to splash out on an expensive renovation (which is always a bonus if you’re renting).Ī galaxy projector is also a great piece of complimentary tech. These devices are surprisingly affordable and a unique way to add some ambience to your home. ![]() If you’ve been looking to change the atmosphere of certain rooms in your home, then allow us to introduce you to the humble galaxy projector. ![]() BTW - prices are accurate and items in stock at the time of posting. We have affiliate and advertising partnerships, which means we may collect a share of sales or other compensation from the links on this page. At Gizmodo, we independently select and write about stuff we love and think you'll like too. The story revolves around their brutal training, the racial prejudices that they have to overcome and finally, their success in battle against German pilots. ![]() lost a lot of its men in battle, 4 black, newly recruited pilots went into training to be the first black squadron to fight for the U.S. The magnificent story of the Fighting 99th (first group of black American pilots who were allowed to fight for their country) is portrayed in The Tuskegee Airmen. HBCU Black History Movies The Tuskegee Airmen (1995) (David Oyelowo) and his brothers and sisters in the movement prompted change that forever altered history. Director Ava DuVernay’s SELMA tells the real story of how the revered leader and visionary Dr. The epic march from Selma to Montgomery culminated in President Johnson (Tom Wilkinson) signing the Voting Rights Act of 1965, one of the most significant victories for the civil rights movement. led a dangerous campaign to secure equal voting rights in the face of violent opposition. The film chronicles the tumultuous three-month period in 1965, when Dr. The is a must see for HBCU students who may be too young to fully understand the Civil Rights movement and the way it changed history for black Americans. who was the spokesman for the boycott movement. The movie focuses more on the leadership of Rev. The one-day boycott that changed the history for black Americans is depicted in the movie, “ Boycott“. Her arrest initiated a series of civil disobedience rallies that led to the Montgomery Bus Boycott. It was December 1955 when Rosa Parks was arrested for refusing to give up her bus seat to a white passenger. Here is our short list of Black History Movies for HBCU students: Civil Rights Black History Movies Boycott (2001) This post contains affiliate links and we will be compensated if you make a purchase after clicking our links. All these films depict the black experience from different perspectives and times in history. So we’ve compiled a list of 10 Black History movies that HBCU students should watch throughout the year to continue learning about their ancestors. ![]() ![]() We love celebrating Black History Month every February, but there is too much of our history to absorb in just one month. The Great Debaters (2007), directed by and starring Denzel Washington and produced by Oprah Winfrey. ![]() Never assign filetypes to open in Thumbnailer, because it doesn't have any capacity to open files. You can't 'open' a design in Embrilliance Thumbnailer, because you'll never need to 'open' a design to see what it is once it's installed. When it is finished, you'll see something like the below image in your File Explorer or Finder, provided you have set your view to see thumbnails or icons as shown in the menu bar. Once Thumbnailer is properly installed, it will start creating icons for your embroidery files as selected. After that, the Control Panel has done its job you very likely will not need to open it again unless Thumbnailer is updated. Most users will click 'Select All' and then click 'OK' to tell Thumbnailer to create their visual icons. ![]() In this window, you'll select all of the files you'd like to see as graphical representations (Thumbnails) instead of plain icons in your file windows. When you install Embrilliance Thumbnailer, the window you are presented is the Control Panel. ![]() Embrilliance Thumbnailer gives your operating system the power to show you a visual representation of your embroidery files in any file selection or file management window. Many users have asked, "How do I use Embrilliance Thumbnailer?" The truth is, you never need to actively 'use' it to get the benefit of easily previewing your designs!Įmbrilliance Thumbnailer isn't a standalone program in which you open designs, it's more like an upgrade for the File Explorer in Windows or the Finder in Mac. ![]() As soon as I tried to work with my cloud, B2 canceled my upload. Unfortunately, I couldn’t get the upload to run in the background. Each time an individual file has been uploaded, a tick appears on the thumbnail for a short time. I can drag and drop files and folders into the box, and they’ll begin uploading automatically. Uploading is simple, I can click the upload tab in an open bucket, and a dialog box will appear. To change any settings, I don’t have to go into the bucket itself I can do everything from the panel. The menu is down the left-hand side, and all my buckets are listed in the center of the page.Įach bucket has its own panel, which displays all the options and settings for it. The web interface isn’t the prettiest I’ve seen, but it’s easy to use. I can also use it on my mobile and through the web interface. I can use B2 on my desktop as a hard drive or as an application. This opens a page where I can see all my existing buckets and create a new one.Įach bucket has an unlimited data capacity, and I can produce up to a hundred on one account. I can create a bucket by clicking on the ‘buckets’ tab located on the left side of the web interface. ![]() I can use them to store related items in and by giving the bucket a unique name, it’s easy to locate. So before I begin storing files, I need to create a bucket.īuckets are excellent organization tools, which work like a virtual container they can hold files and folders. ![]() Signing up is a breeze all it requires is an email address and a secure password.ī2 is an IaaS (Infrastructure-as-a-Service) cloud-based storage. Ease of useīackblaze B2 cloud storage is relatively easy to use. This Backblaze B2 review covers its main features, plus extras and pricing plans. That protein helps package the viral RNA. Most of the rapid antigen tests look for the coronavirus’s nucleocapsid, or N protein. Many of the at-home kits are antigen tests, which probe for certain viral proteins. If any of the viral genetic material is present, then multiple rounds of copying short pieces of certain viral genes should produce a signal. Those tests work by first converting any of the virus’s RNA in the sample into DNA. Those tests are the ones you would encounter most often at the doctor’s office or other testing centers, and some at-home tests allow people to swab themselves and mail the samples to a lab for PCR testing. The PCR (polymerase chain reaction) test determines whether there is viral RNA in the swab or saliva sample being tested. (Antibody tests aren’t diagnostic tests: They can detect evidence of past infections, but not current cases.) Sign up for e-mail updates on the latest coronavirus news and research You can find a list of tests available in stores or at testing sites in the United States here. Both can determine whether you have a current infection with SARS-CoV-2, the virus that causes COVID-19. There are two major categories of diagnostic tests you might encounter: antigen tests and nucleic acid amplification tests, better known as PCR tests. Here are some answers to that and other queries. In particular, she wanted to know if her daughter’s recent vaccine shot would interfere with the results of her home test. And even if you can get your hands on a test, many folks - like my friend - have questions. Consumers have complained that their pharmacies are sold out and that testing centers in some places have long lines. Yet COVID-19 tests aren’t easy to come by everywhere. Some people are making testing part of their routines before holiday gatherings. President Joe Biden announced recently that insurance providers must reimburse people for at-home coronavirus tests, and millions of tests will be available for people who don’t have insurance. Testing has been on lots of other people’s minds and in the news lately, too. Antigen multi-analyte respiratory panel tests authorized in the table below are assigned the QMN product code.A friend texted me recently because her daughter’s class had a coronavirus outbreak and my friend had some questions about COVID-19 testing. To see additional authorization documents, such as letters granting EUA amendments or revisions, and a list of other brand names authorized under a specific EUA, select the plus (+) button beside the "Date EUA Issued or Last Updated" for each EUA.Īuthorized EUA devices in the table below for SARS-CoV-2 antigen diagnostic tests are assigned the QKP product code.
![]() The MacBook Air 15-inch is ideal for everyday computing and some light photo and video editing. ![]() MacBook Air 15-inch M2 review: Graphics and gaming By contrast, the drives in the more expensive 15-inch Air configurations benefit from two NAND chips. What's causing the discrepancy you can see in the numbers above? The 256GB Air performs worse than the 512GB, 1TB and TB versions because its SSD only has a single NAND chipset. Since we first published our review, testing data from MaxTech has shown the base 256GB version of the 15-inch MacBook Air has considerably slower drive performance than the 512GB model. It achieved a 2,793 MBps read speed and 3,145 MBps write speed. Lastly, we ran the Blackmagic disk speed test to measure the 15-inch MacBook Air’s SSD performance. The laptop not only kept on chugging without missing a beat, but it remained cool to the touch the entire time.īlackMagic SSD test (in MBps) Row 0 - Cell 0 During my testing, I had upwards of 20 open tabs open while running a YouTube video. Thanks to its powerful Apple M2 processor, the MacBook Air 15-inch can handle almost anything you throw at it. MacBook Air 15-inch M2 review: Performance Still, the overall sound quality is improved from the 13-inch Air. Bass sounded punchy but not as powerful as on the MacBook Pro 16-inch 2021. All of those disparate elements came through perfectly. I played Dream Theater’s “Alien” at full volume and was impressed by the overall clarity of the song - which has numerous time signature changes and a flurry of guitar and keyboard solos. Sound-wise, this laptop is almost on par with the latest MacBook Pros - which also feature a 6-speaker sound system. The latter’s 4-speaker sound system was pretty good, but the new laptop’s speakers blow it away. One of the most notable upgrades this laptop has over its 13-inch counterpart is its 6-speaker sound system. With regard to non-HDR brightness, the panel averaged 473 nits of brightness - making it brighter than the XPS 15 OLED (371 nits). These values are a smidge lower than the 13-inch model, which was just one point shy of reaching 500 nits of HDR brightness. When viewing HDR content, the laptop got as high as 479 nits of brightness when displaying HDR content on 10% of the display and 480 nits for 100% of the screen. The MacBook Air’s panel can get fairly bright. Both laptops did better in the Delta-E test compared to the XPS 15 OLED (0.24). Regarding color accuracy, the 15-inch MacBook Air turned in a Delta-E score of 0.17 (where 0 is best), compared to the 0.22 its 13-inch counterpart delivered. That dossier, the target of intense derision from Trump, was ultimately provided to the FBI and used by federal authorities as they applied for and received surveillance warrants targeting a former Trump campaign aide.Īccording to the indictment, Danchenko repeatedly lied to the FBI about his sources of information and that deception mattered because the FBI “devoted substantial resources attempting to investigate and corroborate the allegations” in the dossier and had “relied in large part” on that research in obtaining the surveillance warrants.Ī lawyer for Danchenko had no immediate comment. The five-count indictment accuses Danchenko of making multiple false statements to the FBI when interviewed in 2017 about his role in collecting information for Christopher Steele, a former British spy who was paid by Democrats to investigate connections between Trump and Russia.ĭanchenko, a U.S.-based Russian who’d specialized in Russian and Eurasian matters as an analyst at the Brookings Institution think tank, was a significant source for Steele as Steele compiled his dossier of research. But it does endorse a longstanding concern about the Russia probe: that opposition research the FBI relied on was marred by unsupported, uncorroborated claims. ![]() ![]() The case does not undercut investigators’ findings that the Kremlin aided the Trump campaign – findings that were not based on the dossier. The indictment, the third criminal case brought by Durham and the second in a two-month span, is likely to boost complaints from Trump allies that well-connected Democrats worked behind the scenes to advance suspicions about Trump and Russia that contributed to the FBI’s election-year investigation. Pushing Ahead of the Dame - The best source online for every Bowie song. Just getting into Bowie and want to know what to listen to? There's a megathread for that! If you have any self made products that you want to plug (t-shirts, art for sale, pins/badges, etc) that's ok as long as it's unique or interesting, please message the mods first if you are unsure. Post it there! Tierlists and AI content are also not allowed here.Ĭovers and parodies are ok! But if you just want to promote your social media or music career, this ain’t the place.ĭon't be a jerk! Everyone is entitled to their opinion. Along with Kenneth Ascher and Rupert Holmes, they wrote the music and lyrics to A Star Is Born, with Barbra Streisand and Kris Kristofferson.No low effort/quality memes or shitposts, these go to r/davidbowiecirclejerk. He contributed lyrics to the song You’re So Nice to Be Around with music by John Williams, and it earned them a Oscar nomination. Tremendous work from Biff Rose - a near-lost singer-songwriter from the late 60s, barely remembered as the author of Fill Your Heart from David Bowies. Williams has worked on the music of a number of films, including writing and singing on Phantom of the Paradise and Bugsy Malone. He first was a part of a short lived rock group called “Holy Mackerel”. Most recently, he collaborated with Scissor Sisters on their second album, Ta-Dah. North, south, east or west, to everyone all over the world This song. Williams also collaborated with Biff Rose, notably on the song “Fill Your Heart”, originally recorded by Tiny Tim as the B-side of his 1968 hit “Tiptoe Through The Tulips” and subsequently covered by David Bowie on his album Hunky Dory. Fill Your Heart Lyrics And now my dear friends Id like to dedicate this song to all of you out there Wherever you may be. He also wrote the cantata Wings with music by Michel Colombier.Ī frequent cowriter of Williams was musician Kenneth Ascher their songs together included the popular children’s favorite “The Rainbow Connection”, sung by Kermit the Frog in The Muppet Movie. Anne Murray sang “Talk It Over in the Morning”. The song 'Fill Your Heart' is Roses best-known composition. Roses Side, which contained his hit single 'Buzz the Fuzz'. Following the release of 1968s The Thorn in Mrs. Bobby Sherman also sang “Cried Like a Baby”. Music Rose recorded his first two records for Tetragrammaton Records. An early collaboration with Roger Nichols, “Someday Man”, was covered by The Monkees on a 1969 single, and was the first Monkees’ release not published by Screen Gems. “We’ve Only Just Begun” was originally a song for Crocker National Bank television commercial featuring newlyweds. Fill Your Heart With Biff Rose by Biff Rose Song 3:12 English (P) 1968 RPM Records Details Song Lyrics Fill Your Heart Lyrics Fill your heart with love today Dont play the game of time Things that happened in the past Only happened in your Mind Only in your Mind-Forget your Mind And you'll be free-yea The writing's on the wall Free-yea'. ![]() Just remember Lovers never lose Cause they are Free of thoughts unpure sic And of. Williams is responsible for a number of enduring pop hits from the 1970s, including a number of hits for Three Dog Night, Helen Reddy, and The Carpenters, most notably “Rainy Days and Mondays,” “I Won’t Last a Day Without You,” and “We’ve Only Just Begun”, which has since become a cover-band standard and de rigueur for weddings throughout North America. Fill your heart with love today Dont play the game of time Things that happened in the past Only happened in your Mind Only in your Mind-Forget your Mind And youll be free-yea The writings on the wall Free-yea. ![]() is an American musician, composer, songwriter, and actor. |
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